Charge Beam + X-Ray Scope + Speed Booster.Charge Beam + Hi-Jump Boots + Speed Booster.Charge Beam + Speed Booster + Grappling Beam.Charge Beam + Gravity Suit + Speed Booster.There are twenty different routes for the final 3 upgrades:.Required to survive the Laser Brain Attack.Energy Tanks and Reserve Tanks (3 total) (1/2 or 2/1 or 3/0).Required to reduce the damage done by Mother Brain's Laser Brain Attack.Required to open Red and Green Hatches and destroy Mother Brain's Control Capsule.Missiles and Super Missiles (4 total) (2/2 or 1/3).There are 36 total when all four interchangeable beam upgrades are counted as one. Like in Metroid, there is no item percentage and each upgrade rounds up to 3%. Samus starts the game with the Morph Ball, 30 Missiles, and the Long Beam. Required to survive against the Queen Metroid.Required to get around and defeat the Queen Metroid.Defeating Kraid and Ridley will grant 75 Missiles each. There is no item percentage displayed in-game, though each upgrade rounds up to 3%. Much more information can be added to this article. Please help improve this The sections on Samus Returns and Dread need more research on what items can be skipped. 'Multiple mutations will cause a Metroid to grow into an even larger and more powerful adversary.'